diff --git a/src/wp-admin/install.php b/src/wp-admin/install.php
index 8d7e947a8f..6858661662 100644
--- a/src/wp-admin/install.php
+++ b/src/wp-admin/install.php
@@ -193,6 +193,12 @@ if ( ! is_string( $wpdb->base_prefix ) || '' === $wpdb->base_prefix ) {
 	die( '<h1>' . __( 'Configuration Error' ) . '</h1><p>' . __( 'Your <code>wp-config.php</code> file has an empty database table prefix, which is not supported.' ) . '</p></body></html>' );
 }
 
+// Set error message if DO_NOT_UPGRADE_GLOBAL_TABLES isn't set as it will break install.
+if ( defined( 'DO_NOT_UPGRADE_GLOBAL_TABLES' ) && true === DO_NOT_UPGRADE_GLOBAL_TABLES ) {
+	display_header();
+	die( '<h1>' . __( 'Configuration Error' ) . '</h1><p>' . __( 'The constant DO_NOT_UPGRADE_GLOBAL_TABLES cannot be defined when installing WordPress.' ) . '</p></body></html>' );
+}
+
 /**
  * @global string    $wp_local_package
  * @global WP_Locale $wp_locale