diff --git a/src/wp-includes/option.php b/src/wp-includes/option.php
index 8ae0b68595..f6e3eafcdf 100644
--- a/src/wp-includes/option.php
+++ b/src/wp-includes/option.php
@@ -2058,16 +2058,6 @@ function register_initial_settings() {
 			'description'  => __( 'Allow people to post comments on new articles.' ),
 		)
 	);
-
-	register_setting(
-		'permalink',
-		'permalink_structure',
-		array(
-			'show_in_rest' => true,
-			'type'         => 'string',
-			'description'  => __( 'Custom URL structure for permalinks and archives.' ),
-		)
-	);
 }
 
 /**
diff --git a/tests/phpunit/tests/rest-api/rest-settings-controller.php b/tests/phpunit/tests/rest-api/rest-settings-controller.php
index d7b7a9aee9..73805b4d38 100644
--- a/tests/phpunit/tests/rest-api/rest-settings-controller.php
+++ b/tests/phpunit/tests/rest-api/rest-settings-controller.php
@@ -88,7 +88,6 @@ class WP_Test_REST_Settings_Controller extends WP_Test_REST_Controller_Testcase
 			'posts_per_page',
 			'default_ping_status',
 			'default_comment_status',
-			'permalink_structure',
 		);
 
 		if ( ! is_multisite() ) {
diff --git a/tests/qunit/fixtures/wp-api-generated.js b/tests/qunit/fixtures/wp-api-generated.js
index e2c8e8f5c7..7e18cb0104 100644
--- a/tests/qunit/fixtures/wp-api-generated.js
+++ b/tests/qunit/fixtures/wp-api-generated.js
@@ -4634,11 +4634,6 @@ mockedApiResponse.Schema = {
                             ],
                             "description": "Allow people to post comments on new articles.",
                             "type": "string"
-                        },
-                        "permalink_structure": {
-                            "required": false,
-                            "description": "Custom URL structure for permalinks and archives.",
-                            "type": "string"
                         }
                     }
                 }
@@ -6074,6 +6069,5 @@ mockedApiResponse.settings = {
     "default_post_format": "0",
     "posts_per_page": 10,
     "default_ping_status": "open",
-    "default_comment_status": "open",
-    "permalink_structure": null
+    "default_comment_status": "open"
 };