diff --git a/src/wp-includes/media.php b/src/wp-includes/media.php
index 6b0187a932..7b99f95980 100644
--- a/src/wp-includes/media.php
+++ b/src/wp-includes/media.php
@@ -985,7 +985,7 @@ function wp_calculate_image_srcset( $size_array, $image_src, $image_meta, $attac
 	 */
 	$image_meta = apply_filters( 'wp_calculate_image_srcset_meta', $image_meta, $size_array, $image_src, $attachment_id );
 
-	if ( empty( $image_meta['sizes'] ) ) {
+	if ( empty( $image_meta['sizes'] ) || strlen( $image_meta['file'] ) < 4 ) {
 		return false;
 	}
 
@@ -1060,6 +1060,11 @@ function wp_calculate_image_srcset( $size_array, $image_src, $image_meta, $attac
 	 */
 	foreach ( $image_sizes as $image ) {
 
+		// Check if image meta isn't corrupted.
+		if ( ! is_array( $image ) ) {
+			continue;
+		}
+
 		// If the file name is part of the `src`, we've confirmed a match.
 		if ( ! $src_matched && false !== strpos( $image_src, $dirname . $image['file'] ) ) {
 			$src_matched = true;
diff --git a/tests/phpunit/tests/media.php b/tests/phpunit/tests/media.php
index d5ae231c2c..5399f858d3 100644
--- a/tests/phpunit/tests/media.php
+++ b/tests/phpunit/tests/media.php
@@ -1128,6 +1128,74 @@ EOF;
 		$this->assertSame( $expected_srcset, wp_calculate_image_srcset( $size_array, $image_src, $image_meta ) );
 	}
 
+	/**
+	 * @ticket 35480
+	 */
+	function test_wp_calculate_image_srcset_corrupted_image_meta() {
+		$size_array = array( 300, 150 );
+		$image_src = 'http://' . WP_TESTS_DOMAIN . '/wp-content/uploads/2015/12/test-300x150.png';
+		$image_meta = array(
+			'width' => 1600,
+			'height' => 800,
+			'file' => '2015/12/test.png',
+			'sizes' => array(
+				'thumbnail' => array(
+					'file' => 'test-150x150.png',
+					'width' => 150,
+					'height' => 150,
+					'mime-type' => 'image/png',
+				),
+				'medium' => array(
+					'file' => 'test-300x150.png',
+					'width' => 300,
+					'height' => 150,
+					'mime-type' => 'image/png',
+				),
+				'medium_large' => array(
+					'file' => 'test-768x384.png',
+					'width' => 768,
+					'height' => 384,
+					'mime-type' => 'image/png',
+				),
+				'large' => array(
+					'file' => 'test-1024x512.png',
+					'width' => 1024,
+					'height' => 512,
+					'mime-type' => 'image/png',
+				),
+			),
+		);
+
+		$srcset = array(
+			300  => 'http://' . WP_TESTS_DOMAIN . '/wp-content/uploads/2015/12/test-300x150.png 300w',
+			768  => 'http://' . WP_TESTS_DOMAIN . '/wp-content/uploads/2015/12/test-768x384.png 768w',
+			1024 => 'http://' . WP_TESTS_DOMAIN . '/wp-content/uploads/2015/12/test-1024x512.png 1024w',
+			1600 => 'http://' . WP_TESTS_DOMAIN . '/wp-content/uploads/2015/12/test.png 1600w',
+		);
+
+		// No sizes array
+		$image_meta1 = $image_meta;
+		unset( $image_meta1['sizes'] );
+		$this->assertFalse( wp_calculate_image_srcset( $size_array, $image_src, $image_meta1 ) );
+
+		// Sizes is string instead of array; only full size available means no srcset.
+		$image_meta2 = $image_meta;
+		$image_meta2['sizes'] = '';
+		$this->assertFalse( wp_calculate_image_srcset( $size_array, $image_src, $image_meta2 ) );
+
+		// File name is incorrect
+		$image_meta4 = $image_meta;
+		$image_meta4['file'] = '/';
+		$this->assertFalse( wp_calculate_image_srcset( $size_array, $image_src, $image_meta4 ) );
+
+		// Intermediate size is string instead of array.
+		$image_meta3 = $image_meta;
+		$image_meta3['sizes']['medium_large'] = '';
+		unset( $srcset[768] );
+		$expected_srcset = implode( ', ', $srcset );
+		$this->assertSame( $expected_srcset, wp_calculate_image_srcset( $size_array, $image_src, $image_meta3 ) );
+	}
+
 	/**
 	 * @ticket 33641
 	 */