diff --git a/src/wp-includes/blocks.php b/src/wp-includes/blocks.php
index 81207da795..edd30478af 100644
--- a/src/wp-includes/blocks.php
+++ b/src/wp-includes/blocks.php
@@ -897,7 +897,7 @@ function insert_hooked_blocks( &$parsed_anchor_block, $relative_position, $hooke
 		 *
 		 * @since 6.5.0
 		 *
-		 * @param array                           $parsed_hooked_block The parsed block array for the given hooked block type.
+		 * @param array|null                      $parsed_hooked_block The parsed block array for the given hooked block type, or null to suppress the block.
 		 * @param string                          $hooked_block_type   The hooked block type name.
 		 * @param string                          $relative_position   The relative position of the hooked block.
 		 * @param array                           $parsed_anchor_block The anchor block, in parsed block array format.
@@ -913,7 +913,7 @@ function insert_hooked_blocks( &$parsed_anchor_block, $relative_position, $hooke
 		 *
 		 * @since 6.5.0
 		 *
-		 * @param array                           $parsed_hooked_block The parsed block array for the given hooked block type.
+		 * @param array|null                      $parsed_hooked_block The parsed block array for the given hooked block type, or null to suppress the block.
 		 * @param string                          $hooked_block_type   The hooked block type name.
 		 * @param string                          $relative_position   The relative position of the hooked block.
 		 * @param array                           $parsed_anchor_block The anchor block, in parsed block array format.
@@ -922,6 +922,10 @@ function insert_hooked_blocks( &$parsed_anchor_block, $relative_position, $hooke
 		 */
 		$parsed_hooked_block = apply_filters( "hooked_block_{$hooked_block_type}", $parsed_hooked_block, $hooked_block_type, $relative_position, $parsed_anchor_block, $context );
 
+		if ( null === $parsed_hooked_block ) {
+			continue;
+		}
+
 		// It's possible that the filter returned a block of a different type, so we explicitly
 		// look for the original `$hooked_block_type` in the `ignoredHookedBlocks` metadata.
 		if (
@@ -962,6 +966,25 @@ function set_ignored_hooked_blocks_metadata( &$parsed_anchor_block, $relative_po
 		return '';
 	}
 
+	foreach ( $hooked_block_types as $index => $hooked_block_type ) {
+		$parsed_hooked_block = array(
+			'blockName'    => $hooked_block_type,
+			'attrs'        => array(),
+			'innerBlocks'  => array(),
+			'innerContent' => array(),
+		);
+
+		/** This filter is documented in wp-includes/blocks.php */
+		$parsed_hooked_block = apply_filters( 'hooked_block', $parsed_hooked_block, $hooked_block_type, $relative_position, $parsed_anchor_block, $context );
+
+		/** This filter is documented in wp-includes/blocks.php */
+		$parsed_hooked_block = apply_filters( "hooked_block_{$hooked_block_type}", $parsed_hooked_block, $hooked_block_type, $relative_position, $parsed_anchor_block, $context );
+
+		if ( null === $parsed_hooked_block ) {
+			unset( $hooked_block_types[ $index ] );
+		}
+	}
+
 	$previously_ignored_hooked_blocks = isset( $parsed_anchor_block['attrs']['metadata']['ignoredHookedBlocks'] )
 		? $parsed_anchor_block['attrs']['metadata']['ignoredHookedBlocks']
 		: array();
diff --git a/tests/phpunit/tests/blocks/insertHookedBlocks.php b/tests/phpunit/tests/blocks/insertHookedBlocks.php
index d4f5d14502..cf99b213e5 100644
--- a/tests/phpunit/tests/blocks/insertHookedBlocks.php
+++ b/tests/phpunit/tests/blocks/insertHookedBlocks.php
@@ -180,4 +180,42 @@ class Tests_Blocks_InsertHookedBlocks extends WP_UnitTestCase {
 			"Markup wasn't generated correctly for hooked block wrapped in Group block by filter."
 		);
 	}
+
+	/**
+	 * @ticket 60580
+	 *
+	 * @covers ::insert_hooked_blocks
+	 */
+	public function test_insert_hooked_blocks_filter_can_suppress_hooked_block() {
+		$anchor_block = array(
+			'blockName'    => self::ANCHOR_BLOCK_TYPE,
+			'attrs'        => array(
+				'layout' => array(
+					'type' => 'flex',
+				),
+			),
+			'innerContent' => array(),
+		);
+
+		$filter = function ( $parsed_hooked_block, $hooked_block_type, $relative_position, $parsed_anchor_block ) {
+			// Is the hooked block adjacent to the anchor block?
+			if ( 'before' !== $relative_position && 'after' !== $relative_position ) {
+				return $parsed_hooked_block;
+			}
+
+			if (
+				isset( $parsed_anchor_block['attrs']['layout']['type'] ) &&
+				'flex' === $parsed_anchor_block['attrs']['layout']['type']
+			) {
+				return null;
+			}
+
+			return $parsed_hooked_block;
+		};
+		add_filter( 'hooked_block_' . self::HOOKED_BLOCK_TYPE, $filter, 10, 4 );
+		$actual = insert_hooked_blocks( $anchor_block, 'after', self::HOOKED_BLOCKS, array() );
+		remove_filter( 'hooked_block_' . self::HOOKED_BLOCK_TYPE, $filter );
+
+		$this->assertSame( '', $actual, "No markup should've been generated for hooked block suppressed by filter." );
+	}
 }
diff --git a/tests/phpunit/tests/blocks/setIgnoredHookedBlocksMetadata.php b/tests/phpunit/tests/blocks/setIgnoredHookedBlocksMetadata.php
index f9972eea7f..d5e9c4e23f 100644
--- a/tests/phpunit/tests/blocks/setIgnoredHookedBlocksMetadata.php
+++ b/tests/phpunit/tests/blocks/setIgnoredHookedBlocksMetadata.php
@@ -144,4 +144,36 @@ class Tests_Blocks_SetIgnoredHookedBlocksMetadata extends WP_UnitTestCase {
 			$anchor_block['attrs']['metadata']['ignoredHookedBlocks']
 		);
 	}
+
+	/**
+	 * @ticket 60580
+	 *
+	 * @covers ::set_ignored_hooked_blocks_metadata
+	 */
+	public function test_set_ignored_hooked_blocks_metadata_for_block_suppressed_by_filter() {
+		$anchor_block = array(
+			'blockName' => 'tests/anchor-block',
+			'attrs'     => array(),
+		);
+
+		$hooked_blocks = array(
+			'tests/anchor-block' => array(
+				'after' => array( 'tests/hooked-block', 'tests/hooked-block-suppressed-by-filter' ),
+			),
+		);
+
+		$filter = function ( $parsed_hooked_block, $hooked_block_type, $relative_position, $parsed_anchor_block ) {
+			if ( 'tests/anchor-block' === $parsed_anchor_block['blockName'] && 'after' === $relative_position ) {
+				return null;
+			}
+
+			return $parsed_hooked_block;
+		};
+
+		add_filter( 'hooked_block_tests/hooked-block-suppressed-by-filter', $filter, 10, 4 );
+		set_ignored_hooked_blocks_metadata( $anchor_block, 'after', $hooked_blocks, null );
+		remove_filter( 'hooked_block_tests/hooked-block-suppressed-by-filter', $filter );
+
+		$this->assertSame( array( 'tests/hooked-block' ), $anchor_block['attrs']['metadata']['ignoredHookedBlocks'] );
+	}
 }