diff --git a/src/js/_enqueues/lib/comment-reply.js b/src/js/_enqueues/lib/comment-reply.js
index a82fc03c87..be54c350d3 100644
--- a/src/js/_enqueues/lib/comment-reply.js
+++ b/src/js/_enqueues/lib/comment-reply.js
@@ -95,6 +95,18 @@ window.addComment = ( function( window ) {
 		cancelElement.addEventListener( 'touchstart', cancelEvent );
 		cancelElement.addEventListener( 'click',      cancelEvent );
 
+		// Submit the comment form when the user types CTRL or CMD + 'Enter'.
+		var submitFormHandler = function( e ) {
+			if ( ( e.metaKey || e.ctrlKey ) && e.keyCode === 13 ) {
+				commentFormElement.removeEventListener( 'keydown', submitFormHandler );
+				e.preventDefault();
+				// The submit button ID is 'submit' so we can't call commentFormElement.submit(). Click it instead.
+				commentFormElement.submit.click();
+				return false;
+			}
+		}
+		commentFormElement.addEventListener( 'keydown', submitFormHandler );
+
 		var links = replyLinks( context );
 		var element;