diff --git a/wp-admin/admin-header.php b/wp-admin/admin-header.php
index 248897c987..e2eb9bd9a7 100644
--- a/wp-admin/admin-header.php
+++ b/wp-admin/admin-header.php
@@ -107,6 +107,7 @@ if ( wp_script_is( 'customize-loader', 'queue' ) && current_user_can( 'edit_them
 ?>
 
 <div id="wpwrap">
+<a id="wpbody-content-shortcut" tabindex="5" href="#wpbody-content" class="hide-if-no-js screen-reader-text"><?php _e('Skip to main content'); ?></a>
 <?php require(ABSPATH . 'wp-admin/menu-header.php'); ?>
 <div id="wpcontent">
 
@@ -122,7 +123,7 @@ $current_screen->set_parentage( $parent_file );
 
 ?>
 
-<div id="wpbody-content">
+<div id="wpbody-content" tabindex="-1" aria-label="<?php esc_attr_e('Main content'); ?>">
 <?php
 
 $current_screen->render_screen_meta();
diff --git a/wp-admin/js/common.dev.js b/wp-admin/js/common.dev.js
index d3d9e70019..d54584315e 100644
--- a/wp-admin/js/common.dev.js
+++ b/wp-admin/js/common.dev.js
@@ -361,6 +361,10 @@ $(document).ready( function() {
 		});
 	}
 
+	$('#wpbody-content-shortcut').bind('click.wp-skip-to-content', function(e){
+		$('#wpbody-content').focus();
+		e.preventDefault();
+	});
 });
 
 // internal use