diff --git a/src/wp-includes/option.php b/src/wp-includes/option.php
index 1ea26a48bd..48e8676ed2 100644
--- a/src/wp-includes/option.php
+++ b/src/wp-includes/option.php
@@ -361,18 +361,19 @@ function wp_load_alloptions( $force_cache = false ) {
 }
 
 /**
- * Loads and caches certain often requested site options if is_multisite() and a persistent cache is not being used.
+ * Loads and primes caches of certain often requested network options if is_multisite().
  *
  * @since 3.0.0
+ * @since 6.3.0 Also prime caches for network options when persistent object cache is enabled.
  *
  * @global wpdb $wpdb WordPress database abstraction object.
  *
- * @param int $network_id Optional site ID for which to query the options. Defaults to the current site.
+ * @param int $network_id Optional. Network ID of network for which to prime network options cache. Defaults to current network.
  */
 function wp_load_core_site_options( $network_id = null ) {
 	global $wpdb;
 
-	if ( ! is_multisite() || wp_using_ext_object_cache() || wp_installing() ) {
+	if ( ! is_multisite() || wp_installing() ) {
 		return;
 	}
 
@@ -382,6 +383,16 @@ function wp_load_core_site_options( $network_id = null ) {
 
 	$core_options = array( 'site_name', 'siteurl', 'active_sitewide_plugins', '_site_transient_timeout_theme_roots', '_site_transient_theme_roots', 'site_admins', 'can_compress_scripts', 'global_terms_enabled', 'ms_files_rewriting' );
 
+	if ( wp_using_ext_object_cache() ) {
+		$cache_keys = array();
+		foreach ( $core_options as $option ) {
+			$cache_keys[] = "{$network_id}:{$option}";
+		}
+		wp_cache_get_multiple( $cache_keys, 'site-options' );
+
+		return;
+	}
+
 	$core_options_in = "'" . implode( "', '", $core_options ) . "'";
 	$options         = $wpdb->get_results( $wpdb->prepare( "SELECT meta_key, meta_value FROM $wpdb->sitemeta WHERE meta_key IN ($core_options_in) AND site_id = %d", $network_id ) );